High Quality 99% Abiraterone Acetate CAS NO : 154229-19-3
Product Description
<Span style="font-size: 18px;">Abiraterone
Introduction
Abiraterone acetate, the active ingredient of ZYTIGA is the acetyl ester of abiraterone. Abiraterone is an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase). Each ZYTIGA tablet contains 250 mg of abiraterone acetate. Abiraterone acetate is designated chemically as (3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate
Abiraterone acetate is a white to off-white, non-hygroscopic, crystalline powder. Its molecular formula is C26H33NO2and it has a molecular weight of 391.55. Abiraterone acetate is a lipophilic compound with an octanol-water partition coefficient of 5.12 (Log P) and is practically insoluble in water. The pKa of the aromatic nitrogen is 5.19.
Inactive ingredients in the tablets are colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.
English name: Abiraterone acetate
Synonyms:Abirateroneacetate;CB 7630;(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate
Specification: 98%
CAS NO.:154229-18-2
Appearance: White crystalline powder
Molecular weight: 391.55
Molecular formula:C26H33NO2
Function
Abiraterone is a drug used in castration-resistant prostate cancer. It is formulated as the prodrug abiraterone acetate. Abiraterone can be used as a prostate cancer drug treatment. Abiraterone is a inhibitor of CYP17. It can be used to treat CRPC.
Application
Abiraterone is used as pharmaceutical raw material.
Specification
Items | Specifications | Results |
Appearance | White or off white crystalline powder | white crystalline powder |
|
Identification | The retention time of the major peak in the chromatogram of the test preparation corresponds to that in the chromatogram of the reference preparation | Complies |
Related Substance | Single impurity ≤0.5% Total impurity ≤1.0% | 0.28% 0.32% |
Moisture | ≤0.5% | 0.11% |
Residue on ignition | ≤0.1% | 0.02% |
Heavy metal | ≤10ppm | Complies |
Assay (dry basis) | Not less than 99.0% (HPLC) | 99.7% |
Conclusion: The product conforms to the In-house standard | ||
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Product Categories : Fluorinated Silicone Rubber
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